Millwall's unlucky start to the season continued as a late effort from Curtis Davies sent Luton to the top of the Championship table and kept The Lions rooted to bottom spot.
It was another bitter blow for Colin Lee's luckless Lions, who clearly deserved something from the match following a stirring second-half display.
Once again boss Lee was forced to shuffle his pack with new signing Carl Asaba missing from the team after sustaining a hamstring injury on his debut against Ipswich at the weekend.
In came Ben May, Marvin Elliott, Sammy Igoe and Tony Craig for Josh Simpson, Carlos Fangueiro, Barry Hayles and the injured Asaba.
Lee started out with yet another new formation, this time employing 3-5-2, hoping that by putting Jamie Vincent between the inexperienced Mark Phillips and Paul Robinson at centre half would help to shore up the backline.
It took The Lions some time to adapt to their latest system, but by then Luton had already edged ahead.
Twice the Hatters had threatened from distance in the opening exchanges, but it proved to be third time lucky when Warren Feeney drilled home a crisp 20-yarder with 12 minutes on the clock.
Eight minutes later Steve Robinson fired over, and with the home side piling forward, it only seemed a matter of time before they would increase their tally.
However with Millwall, inspired by the magnificent Vincent, slowly but surely steadying the ship, it was the visitors' turn to ask questions of the home defence.
The hard-working May controlled the ball on the edge of the area only to crack his shot wide of the target before defender Paul Robinson headed over from a dangerous Vincent corner.
Lee's men finished the half strongly, and came out after the break with a really positive look about them. WIthin seconds of the restart that feeling was further enhanced when Elliott's persistence on the right enabled the midfielder to thread the ball square into the box for May to drill home his second goal in successive matches.
Luton had a good claim for a penalty turned down five minutes later when Vincent appeared to impede Feeney in the area, whilst at the other end Jody Morris went close with a rasping left-foot drive that flew a yard wide of Marlon Beresford's left-hand post.
WIth the impatient home crowd getting on their back, Luton looked increasingly nervous and ill at ease for a team flying high in the League. As the half progressed if there was one team going to take the three points, Millwall looked more likely to do so.
Sadly, that didn't prove to be the case. Adrian Serioux replaced the tiring Elliott 15 minutes from time with Millwall preparing to defend a free-kick, but bthey were caught cold when Kevin Nicholls whipped in a delivery, the ball was half-cleared and there was Davis to fire home from close range.
Josh Simpson was introduced for the final five minutes for Mark Phillips, but despite threatening briefly, The Lions were unable to get the ball into the danger zone and put a rocky Hatters rearguard under pressure.

Luton Town: Beresford, Foley, Underwood, Nicholls, Feeney (Edwards, 85mins), Robinson, Showunmi (Coyne, 66mins), Brkovic, Davies, Morgan (Davis, 55mins), Heikkinen. Subs not used: Holmes, Brill.
Booking: Heikkinen (40mins)
Scorers: Feeney (12mins), Davies (77mins)

Millwall: Marshall, Vincent, Elliott (Serioux, 77mins), Robinson, Phillips (Simpson, 85mins), Dunne, Livermore, Craig, Igoe (Hayles, 70mins), May, Morris. Subs not used: Jones, Hutchison.
Booking: Craig (35mins)
Scorer: May (46mins)

Ref: M. Atkinson